1.2.2.Synthesis, crystal structure and in vitro anti-tumor activity of dibutyltin complex of 2,4-dichloro-5-fluorobenzoic acid

Abstract

The dibutyltin complex of 2,4-dichloro-5-

fluorobenzoic acid, [(2,4-Cl2 -5-FC6 H2 C(O)OSnBu2 )2 O]2 (Bu =

CH2 CH2 CH2 CH3 ) (1 ), has been synthesized and characterized

by elemental analysis, FT-IR, 119 Sn NMR spectroscopy, and Xray

single crystal diffraction. Compound 1 is a centrosymmetric

dimmer with two distinct types of carboxylate moieties and tin

atoms with distorted trigonal bipyramidal geometries. The in

vitro  anti-tumor activity of 1 against two human tumor cell lines

was found to be higher than that for cis-platin [cis diaminedichloroplatinum(

II)] used clinically.

Supporting information : FT-IR, 119 Sn NMR, X-Ray, Proliferation

inhibitory rate, Cif file.